Mari Aikio Selected Research

Collagen Type XVIII (Type XVIII Collagen)

1/2020	Lack of collagen XVIII leads to lipodystrophy and perturbs hepatic glucose and lipid homeostasis.
1/2017	Collagen XVIII in tissue homeostasis and dysregulation - Lessons learned from model organisms and human patients.
1/2016	Absence of collagen XVIII in mice causes age-related insufficiency in retinal pigment epithelium proteostasis.
8/2015	Endostatin induces proliferation of oral carcinoma cells but its effect on invasion is modified by the tumor microenvironment.
7/2014	Specific collagen XVIII isoforms promote adipose tissue accrual via mechanisms determining adipocyte number and affect fat deposition.
1/2014	Basement membrane zone collagens XV and XVIII/proteoglycans mediate leukocyte influx in renal ischemia/reperfusion.
11/2013	Collagen XVIII short isoform is critical for retinal vascularization, and overexpression of the Tsp-1 domain affects eye growth and cataract formation.

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Mari Aikio Research Topics

Disease

4	Neoplasms (Cancer) 01/2019 - 01/2012
2	Inflammation (Inflammations) 01/2017 - 01/2014
2	Carcinoma (Carcinomatosis) 08/2015 - 01/2012
1	Insulin Resistance 01/2020
1	Glucose Intolerance 01/2020
1	Lipodystrophy 01/2020
1	Squamous Cell Carcinoma of Head and Neck 01/2019
1	Rare Diseases (Rare Disease) 01/2017
1	Choroidal Neovascularization 01/2016
1	Abdominal Obesity 07/2014
1	Hypertriglyceridemia 07/2014
1	Ischemia 01/2014
1	Lens Subluxation 11/2013
1	Hemorrhage 11/2013
1	Cataract (Cataracts) 11/2013
1	Hypoxia (Hypoxemia) 01/2012
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2012

Drug/Important Bio-Agent (IBA)

7	Collagen Type XVIII (Type XVIII Collagen)IBA 01/2020 - 11/2013
3	EndostatinsIBA 01/2017 - 11/2013
3	CollagenIBA 07/2014 - 01/2012
2	Protein Isoforms (Isoforms)IBA 01/2020 - 11/2013
2	Angiogenesis InhibitorsIBA 08/2015 - 01/2012
1	Triglycerides (Triacylglycerol)IBA 01/2020
1	Glucose (Dextrose)FDA LinkGeneric 01/2020
1	LipidsIBA 01/2020
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 01/2019
1	Matrix Metalloproteinases (MMPs)IBA 01/2019
1	Biological ProductsIBA 01/2017
1	Proteins (Proteins, Gene)FDA Link 01/2016
1	Nonesterified Fatty Acids (NEFA)IBA 07/2014
1	Proteoglycans (Proteoglycan)IBA 01/2014
1	Urea (Carbamide)FDA LinkGeneric 01/2014
1	Retinaldehyde (Retinal)IBA 11/2013
1	Thrombospondin 1IBA 11/2013
1	IntegrinsIBA 01/2012

Therapy/Procedure

1	Drug Therapy (Chemotherapy) 01/2012